How a Mosquito Operates (1912)
This was McCay’s next experiment, but this time he focused on the action live subjects can sometimes repeat. It ultimately strengthens the uncanny valley effect his films can often impart while simultaneously undermining some of the naturalistic motion he introduced in Little Nemo. Nevertheless, the film presents a gruesome little comedy with a truly unsettling effect of the mosquito filling up from sucking the blood out of a man.
https://www.youtube.com/watch?v=1uLWbuButIE